Abstract

It is important to conduct early desensitization test in patients with aspirin hypersensitivity due to the lack of evidence supporting aspirin-free antithrombotic therapy after a percutaneous coronary intervention. Desensitization is relatively fast and effective, and its few absolute contraindications are very rare (Stevens-Johnsons syndrome, toxic epidermal necrolysis, aseptic meningitis, and multiform erythema). After a failed desensitization attempt, a desensitization protocol must be modified and restarted, preferentially after raising the final dose of aspirin and consulting with an allergist. Desensitization protocols share a similar efficacy level unrelated to the duration of the protocol, but protocols with more than 6 different aspirin doses have shown to be more effective. Protocols can be modified to best fit patient needs and hospital resources. Aspirin desensitization using the same protocols can also be done for the optimal management of peripheral artery disease, ischemic stroke, and preeclampsia prophylaxis. For obtaining small aspirin doses, Tartu University Hospital’s pharmacy uses a 3D drug printer.