Abstract

Lesions to the area postrema may lead to area postrema syndrome (APS), which is defined as intractable nausea, vomiting, or hiccups, persisting for at least 48 hours. Since 2015, APS has been considered one of the core clinical characteristics for neuromyelitis optica spectrum disorders (NMOSD), a group of central nervous system inflammatory autoimmune demyelinating diseases. In this case study, the diagnosis criteria for NMOSD were not met and APS remains the diagnosis for now. As APS is commonly encountered either in isolation or accompanying other symptoms at the onset or during NMOSD, the patient remains under observation for further developments.