Abstract

Aim. Comparative electronmicroscopic study of bone repair after internal fracture, osteotomy and perforation was performed. The study focused on tibia repair during the first post-traumatic weeks.
Subjects and methods. Altogether 72 male Wistar rats (200–220 g), subdivided in the case of osteotomy and perforation into the control, training (swimming) and immobilization groups, were involved in the experiments.
Results. Although the stages of bone repair were in general similar in all groups, the repair process was dependent on the mode and degree of injury, thus being different in the experimental  groups (with indirect ossification after internal fracture; primary periosteal, secondary endosteal ossification after osteotomy and primary endosteal, secondary periosteal ossification after perforation). Training had a stimulating and immobilization – inhibiting influence on bone repair.
Conclusion. The results gave information about intracellular changes and intercellular matrix synthesis (formation of the callus and its changes) and confirmed our previous reports on similar post-traumatic bone repair studies where basically routine histology, histomorphometry and immunohistochemistry were used.