Abstract

Persons with synchronous or metachronous primary cancers should be consulted by medical geneticist due to their higher risk of having a hereditary cancer syndrome. In this article we describe some syndromes with multiple primary cancers diagnosed in Estonia: hereditary breast and ovarian cancer syndrome, Lynch syndrome, multiple endocrine neoplasia syndromes, DICER1 and constitutional mismatch repair deficiency syndrome. Also we explain the different heredity models connected to this tumours. Genetic tests are helpful for giving more precise prognosis, accurate therapy and identifing the at risk relatives.