Abstract

‘Iodine allergy’ is a scientifically-unsupported term for describing the side effects of iodine-containing contrast agents. Adverse reactions caused by contrast agents may be based on physicochemical properties of the contrast agent or, more rarely, immunemediated hypersensitivity reactions. Side effects are uncommon, especially hypersensitivity reactions, but their possibility must always be considered, as they can occur both during initial or subsequent administrations. It’s important for healthcare providers to anticipate, recognize, and manage these reactions effectively. Reducing the risk of recurrent hypersensitivity reactions may require the use of alternative imaging methods, switching contrast agents, referring patients to allergologist-immunologists, and in rare cases, premedication. It is equally
important to avoid unnecessary cancellations of necessary diagnostic procedures, which could delay essential diagnosis or treatment.