{"id":10991,"date":"2020-05-27T09:39:20","date_gmt":"2020-05-27T07:39:20","guid":{"rendered":"https:\/\/eestiarst.ee\/en\/?p=10991"},"modified":"2020-05-27T09:39:20","modified_gmt":"2020-05-27T07:39:20","slug":"establishment-of-complete-blood-count-reference-values-for-estonian-adults","status":"publish","type":"post","link":"https:\/\/eestiarst.ee\/en\/establishment-of-complete-blood-count-reference-values-for-estonian-adults\/","title":{"rendered":"Establishment of complete blood count reference values for Estonian adults"},"content":{"rendered":"<p><strong>Objectives.<\/strong> Complete blood count (CBC) is one of the most commonly requested laboratory tests in clinical practice.\u00a0 The interpretation of laboratory results is a comparative decision-making process, and reference intervals have an important role in laboratory reports. In Estonia, each laboratory uses its \u201cown\u201d reference values for CBC. A difference between reference ranges causes confusion in the interpretation of results. The aim of the study was to develop common reference values for CBC in adults.<\/p>\n<p><strong>Methods.<\/strong> The collaborating four laboratories recruited first time blood donors and appropriate healthy volunteers by invitation, drew blood, and measured CBC-diff parameters. The participants had to feel subjectively well, did not have a history of chronic disease or use of prescription medications. They were assessed by using completed questionnaires and defined exclusion criteria. The EDTA blood samples were tested within 3 hours after collection. The CBC-diff parameters were measured by the Sysmex analysers XE-2100, XE-5000, XN-2000, XN-1000 (Kobe, Japan). Each participating laboratory has been accredited according to ISO 15189:2012. A nonparametric method was used to calculate the reference ranges.<\/p>\n<p><strong>Results.<\/strong> Blood samples from a total of 314 clinically asymptomatic and apparently healthy subjects were evaluated and a final of 259 subjects were included in the study: 132 men and 127 women. The reference intervals were calculated for the following parameters: RBC, Hb, Hct, MCV, MCH, MCHC, RDW, Plt, MPV, Pct, P-LCR, PDW, IPF, WBC, IG#, Neut#, Lymph#, Mono#, Baso#, Eo#.<\/p>\n<p><strong>Conclusions.<\/strong> Population based CBC reference ranges were established. The results provide the basis for harmonization of automated CBC\u2013diff reference intervals across laboratories. This would assist laboratory specialists and clinicians in gaining a uniform interpretation of test results for clinical management of patients.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Objectives. Complete blood count (CBC) is one of the most commonly requested laboratory tests in clinical practice.\u00a0 The interpretation of laboratory results is a comparative decision-making process, and reference intervals have an important role in laboratory reports. In Estonia, each laboratory uses its \u201cown\u201d reference values for CBC. A difference between reference ranges causes confusion &#8230;<\/p>\n","protected":false},"author":5,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[2],"tags":[1540],"class_list":["post-10991","post","type-post","status-publish","format-standard","hentry","category-articles","tag-research"],"acf":[],"_links":{"self":[{"href":"https:\/\/eestiarst.ee\/en\/wp-json\/wp\/v2\/posts\/10991","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/eestiarst.ee\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/eestiarst.ee\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/eestiarst.ee\/en\/wp-json\/wp\/v2\/users\/5"}],"replies":[{"embeddable":true,"href":"https:\/\/eestiarst.ee\/en\/wp-json\/wp\/v2\/comments?post=10991"}],"version-history":[{"count":1,"href":"https:\/\/eestiarst.ee\/en\/wp-json\/wp\/v2\/posts\/10991\/revisions"}],"predecessor-version":[{"id":10992,"href":"https:\/\/eestiarst.ee\/en\/wp-json\/wp\/v2\/posts\/10991\/revisions\/10992"}],"wp:attachment":[{"href":"https:\/\/eestiarst.ee\/en\/wp-json\/wp\/v2\/media?parent=10991"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/eestiarst.ee\/en\/wp-json\/wp\/v2\/categories?post=10991"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/eestiarst.ee\/en\/wp-json\/wp\/v2\/tags?post=10991"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}