{"id":12478,"date":"2022-06-20T09:08:38","date_gmt":"2022-06-20T07:08:38","guid":{"rendered":"https:\/\/eestiarst.ee\/en\/?p=12478"},"modified":"2022-06-20T09:08:38","modified_gmt":"2022-06-20T07:08:38","slug":"interferons-and-covid-19-impact-on-disease-severity-and-applications-in-treatment","status":"publish","type":"post","link":"https:\/\/eestiarst.ee\/en\/interferons-and-covid-19-impact-on-disease-severity-and-applications-in-treatment\/","title":{"rendered":"Interferons and COVID-19: impact on disease severity and applications in treatment"},"content":{"rendered":"<p>Type I and type III interferons (IFNs) are antiviral proteins secreted from virusinfected cells. The severe course of COVID-19 is characterized by inadequately low type I and type III IFN levels during the early disease phase: SARS-CoV-2 encodes proteins capable of inhibiting the antiviral defence of the host, which enables rapid viral replication. Inhalable type I and type III IFN-s<br \/>\nare potential COVID-19 drug candidates that could drastically reduce the risk of developing severe disease.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Type I and type III interferons (IFNs) are antiviral proteins secreted from virusinfected cells. The severe course of COVID-19 is characterized by inadequately low type I and type III IFN levels during the early disease phase: SARS-CoV-2 encodes proteins capable of inhibiting the antiviral defence of the host, which enables rapid viral replication. Inhalable type &#8230;<\/p>\n","protected":false},"author":5,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[2],"tags":[1538],"class_list":["post-12478","post","type-post","status-publish","format-standard","hentry","category-articles","tag-review","authors-martti-vanker"],"acf":[],"_links":{"self":[{"href":"https:\/\/eestiarst.ee\/en\/wp-json\/wp\/v2\/posts\/12478","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/eestiarst.ee\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/eestiarst.ee\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/eestiarst.ee\/en\/wp-json\/wp\/v2\/users\/5"}],"replies":[{"embeddable":true,"href":"https:\/\/eestiarst.ee\/en\/wp-json\/wp\/v2\/comments?post=12478"}],"version-history":[{"count":1,"href":"https:\/\/eestiarst.ee\/en\/wp-json\/wp\/v2\/posts\/12478\/revisions"}],"predecessor-version":[{"id":12479,"href":"https:\/\/eestiarst.ee\/en\/wp-json\/wp\/v2\/posts\/12478\/revisions\/12479"}],"wp:attachment":[{"href":"https:\/\/eestiarst.ee\/en\/wp-json\/wp\/v2\/media?parent=12478"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/eestiarst.ee\/en\/wp-json\/wp\/v2\/categories?post=12478"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/eestiarst.ee\/en\/wp-json\/wp\/v2\/tags?post=12478"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}