{"id":12917,"date":"2023-01-20T10:54:51","date_gmt":"2023-01-20T08:54:51","guid":{"rendered":"https:\/\/eestiarst.ee\/en\/?p=12917"},"modified":"2023-01-20T10:54:51","modified_gmt":"2023-01-20T08:54:51","slug":"igg4-related-disease-an-immunemediated-disease-with-many-faces","status":"publish","type":"post","link":"https:\/\/eestiarst.ee\/en\/igg4-related-disease-an-immunemediated-disease-with-many-faces\/","title":{"rendered":"IgG4-Related Disease \u2013 an immunemediated disease with many faces"},"content":{"rendered":"<p>IgG4-related disease (IgG4-RD) is a chronic immune-mediated condition that can affect almost any organ. The disease is characterized by IgG4+ plasma cell- rich infiltrates, fibrosis, obliterative phlebitis; in most cases IgG4 serum concentrations are also elevated. IgG4-RD primarily affects middle-aged and older males. This disease often takes many years to diagnose, because of its mimicking characteristics. To facilitate recognition of IgG4-RD, clinical phenotypes can be used. These phenotypes are pancreato-biliary involvement, retroperitoneal fibrosis with or without aortitis, head and neck limited form and Mikulicz\u2019s syndrome with systemic involvement. These phenotypes also represent the most common sites of IgG4-RD. All aspects of this disease are not yet known, nevertheless, IgG4-RD can be diagnosed based on clinical characteristics, histology, serology, radiological evaluation, and glucocorticoids` responsiveness. Early diagnosis, appropriate treatment and avoiding relapses<br \/>\nare crucial to avoid organ damage and to improve prognosis.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>IgG4-related disease (IgG4-RD) is a chronic immune-mediated condition that can affect almost any organ. The disease is characterized by IgG4+ plasma cell- rich infiltrates, fibrosis, obliterative phlebitis; in most cases IgG4 serum concentrations are also elevated. IgG4-RD primarily affects middle-aged and older males. This disease often takes many years to diagnose, because of its mimicking &#8230;<\/p>\n","protected":false},"author":5,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[2],"tags":[1538],"class_list":["post-12917","post","type-post","status-publish","format-standard","hentry","category-articles","tag-review","authors-maris-tulk"],"acf":[],"_links":{"self":[{"href":"https:\/\/eestiarst.ee\/en\/wp-json\/wp\/v2\/posts\/12917","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/eestiarst.ee\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/eestiarst.ee\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/eestiarst.ee\/en\/wp-json\/wp\/v2\/users\/5"}],"replies":[{"embeddable":true,"href":"https:\/\/eestiarst.ee\/en\/wp-json\/wp\/v2\/comments?post=12917"}],"version-history":[{"count":1,"href":"https:\/\/eestiarst.ee\/en\/wp-json\/wp\/v2\/posts\/12917\/revisions"}],"predecessor-version":[{"id":12918,"href":"https:\/\/eestiarst.ee\/en\/wp-json\/wp\/v2\/posts\/12917\/revisions\/12918"}],"wp:attachment":[{"href":"https:\/\/eestiarst.ee\/en\/wp-json\/wp\/v2\/media?parent=12917"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/eestiarst.ee\/en\/wp-json\/wp\/v2\/categories?post=12917"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/eestiarst.ee\/en\/wp-json\/wp\/v2\/tags?post=12917"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}