Chimeric antigene receptor-expressing T cells or so-called CAR-T cells or CAR-Ts represent a group of pharmaceuticals with a novel mechanism of action and is indicated for the treatment of some haematological malignancies. Unlike normal T cells, the CAR-T cells can recognize tumour antigenes independently of major histocompatibility proteins, making them more effective compared to normal T cells. CAR-T cells belong to the group of pharmaceuticals called advanced therapy medicinal products
\n(ATMP), a group of drugs that are regulatively placed under biological medicinal products. First CAR-T cells reached the EU market in 2018, and since April 2023, six CAR-T cell-based pharmaceuticals have held marketing authorisation in the EU. In
\nparallel to the fact that CAR-Ts are the most widely employed ATMPs to date, development in this field is very intense aiming to design CAR-Ts that demonstrate a higher benefit-risk ratio, as well as have the ability to treat solid tumours. This review addresses
\nthe following topics: regulatory background of CAR-Ts, T-cells as the starting material of CAR-Ts, specificities of their manufacturing and the mechanism of action; in addition, some examples of the future scenarios of these drugs are given.<\/p>\n","protected":false},"excerpt":{"rendered":"
Chimeric antigene receptor-expressing T cells or so-called CAR-T cells or CAR-Ts represent a group of pharmaceuticals with a novel mechanism of action and is indicated for the treatment of some haematological malignancies. Unlike normal T cells, the CAR-T cells can recognize tumour antigenes independently of major histocompatibility proteins, making them more effective compared to normal …<\/p>\n","protected":false},"author":5,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[2],"tags":[1538],"class_list":["post-13176","post","type-post","status-publish","format-standard","hentry","category-articles","tag-review","authors-pille-saalik","authors-triin-suvi"],"acf":[],"_links":{"self":[{"href":"https:\/\/eestiarst.ee\/en\/wp-json\/wp\/v2\/posts\/13176","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/eestiarst.ee\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/eestiarst.ee\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/eestiarst.ee\/en\/wp-json\/wp\/v2\/users\/5"}],"replies":[{"embeddable":true,"href":"https:\/\/eestiarst.ee\/en\/wp-json\/wp\/v2\/comments?post=13176"}],"version-history":[{"count":1,"href":"https:\/\/eestiarst.ee\/en\/wp-json\/wp\/v2\/posts\/13176\/revisions"}],"predecessor-version":[{"id":13177,"href":"https:\/\/eestiarst.ee\/en\/wp-json\/wp\/v2\/posts\/13176\/revisions\/13177"}],"wp:attachment":[{"href":"https:\/\/eestiarst.ee\/en\/wp-json\/wp\/v2\/media?parent=13176"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/eestiarst.ee\/en\/wp-json\/wp\/v2\/categories?post=13176"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/eestiarst.ee\/en\/wp-json\/wp\/v2\/tags?post=13176"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}