{"id":16080,"date":"2026-05-18T08:00:54","date_gmt":"2026-05-18T06:00:54","guid":{"rendered":"https:\/\/eestiarst.ee\/?p=16080"},"modified":"2026-05-18T08:00:54","modified_gmt":"2026-05-18T06:00:54","slug":"integration-of-disease-specific-assessment-scales-for-myasthenia-into-neurologists-daily-practice","status":"publish","type":"post","link":"https:\/\/eestiarst.ee\/en\/integration-of-disease-specific-assessment-scales-for-myasthenia-into-neurologists-daily-practice\/","title":{"rendered":"Integration of Disease-Specific Assessment Scales for Myasthenia into Neurologists\u2019 Daily Practice"},"content":{"rendered":"<p><strong>Background.<\/strong> Myasthenia gravis (MG) is a chronic autoimmune neuromuscular disorder characterised by fluctuating muscle weakness and fatigability. Due to the variability of symptoms, single clinical assessments may not accurately reflect disease activity. Disease-specific outcome measures, including patient-reported outcome tools, are therefore recommended for routine clinical practice and research.<br \/>\n<strong>Objective.<\/strong> The aim of this study was to translate, culturally adapt and validate the Myasthenia Gravis Activities of Daily Living (MG-ADL) questionnaire and the Myasthenia Gravis Quality of Life 15-item questionnaire (MG-QOL15) into Estonian, and to evaluate their psychometric properties.<br \/>\n<strong>Methods.<\/strong> Twenty-six adult patients with a confirmed diagnosis of myasthenia gravis were recruited from Tartu University Hospital. The MG-ADL and MG-QOL15 questionnaires were translated into Estonian using a standardised linguistic validation process. Patients completed the questionnaires twice, with a 2\u20133-day interval. Internal consistency was assessed using Cronbach\u2019s alpha, test\u2013retest reliability using weighted Cohen\u2019s kappa, and construct validity using Spearman correlation analyses with Quantitative Myasthenia Gravis (QMG) and Myasthenia Gravis Composite (MGC) scores.<br \/>\n<strong>Results.<\/strong> The Estonian version of MG-ADL (MG-ADL-E) demonstrated acceptable internal consistency (Cronbach\u2019s \u03b1 = 0.76), while the Estonian MG-QOL15 (MG-QOL15-E) showed excellent internal consistency (Cronbach\u2019s \u03b1 = 0.97). Test\u2013retest reliability was good for both instruments (weighted \u03ba = 0.75 for MG-ADL-E and 0.74 for MG-QOL15- E; p &lt; 0.001). MG-ADL-E correlated strongly with MG-QOL15-E and MGC scores, and moderately with QMG scores. MG-QOL15-E showed moderate correlations with both objective clinical scales. <strong>Conclusions.<\/strong> The Estonian versions of MG-ADL and MG-QOL15 are valid and reliable patient-reported outcome measures. Their implementation in clinical practice enables standardised, patient-centred assessment of disease severity and quality of life in individuals with myasthenia gravis and supports contemporary clinical decisionmaking in Estonia.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Background. Myasthenia gravis (MG) is a chronic autoimmune neuromuscular disorder characterised by fluctuating muscle weakness and fatigability. Due to the variability of symptoms, single clinical assessments may not accurately reflect disease activity. Disease-specific outcome measures, including patient-reported outcome tools, are therefore recommended for routine clinical practice and research. Objective. The aim of this study was &#8230;<\/p>\n","protected":false},"author":5,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[2],"tags":[1540],"class_list":["post-16080","post","type-post","status-publish","format-standard","hentry","category-articles","tag-research","authors-perve-et-al"],"acf":[],"_links":{"self":[{"href":"https:\/\/eestiarst.ee\/en\/wp-json\/wp\/v2\/posts\/16080","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/eestiarst.ee\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/eestiarst.ee\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/eestiarst.ee\/en\/wp-json\/wp\/v2\/users\/5"}],"replies":[{"embeddable":true,"href":"https:\/\/eestiarst.ee\/en\/wp-json\/wp\/v2\/comments?post=16080"}],"version-history":[{"count":1,"href":"https:\/\/eestiarst.ee\/en\/wp-json\/wp\/v2\/posts\/16080\/revisions"}],"predecessor-version":[{"id":16081,"href":"https:\/\/eestiarst.ee\/en\/wp-json\/wp\/v2\/posts\/16080\/revisions\/16081"}],"wp:attachment":[{"href":"https:\/\/eestiarst.ee\/en\/wp-json\/wp\/v2\/media?parent=16080"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/eestiarst.ee\/en\/wp-json\/wp\/v2\/categories?post=16080"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/eestiarst.ee\/en\/wp-json\/wp\/v2\/tags?post=16080"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}