{"id":16145,"date":"2026-06-17T17:07:53","date_gmt":"2026-06-17T15:07:53","guid":{"rendered":"https:\/\/eestiarst.ee\/?p=16145"},"modified":"2026-06-17T17:07:53","modified_gmt":"2026-06-17T15:07:53","slug":"autosomal-dominant-hypophosphatemic-rickets-case-report-and-literature-review","status":"publish","type":"post","link":"https:\/\/eestiarst.ee\/en\/autosomal-dominant-hypophosphatemic-rickets-case-report-and-literature-review\/","title":{"rendered":"Autosomal dominant hypophosphatemic rickets \u2013 case report and literature review"},"content":{"rendered":"<p>Autosomal dominant hypophosphatemic rickets (ADHR) is a rare genetic disease caused by a heterozygous mutation in the FGF23 (fibroblast growth factor 23) gene. The disease causes phosphate deficiency which in turn will lead to rickets or osteomalacia. Symptoms usually include musculoskeletal pain, skeletal abnormalities, or bone fractures. In this article we present a case report of a 45-year-old patient and a review of the existing literature. The patient had pain from stress fractures caused by the hypophosphatemic osteomalacia but responded well to treatment with oral phosphate replacement and cholecalciferol. Despite the rarity of the disease, early diagnosis and treatment is particularly important to avoid pain, fractures and decrease in the quality of life.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Autosomal dominant hypophosphatemic rickets (ADHR) is a rare genetic disease caused by a heterozygous mutation in the FGF23 (fibroblast growth factor 23) gene. The disease causes phosphate deficiency which in turn will lead to rickets or osteomalacia. Symptoms usually include musculoskeletal pain, skeletal abnormalities, or bone fractures. In this article we present a case report &#8230;<\/p>\n","protected":false},"author":5,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[2],"tags":[1539],"class_list":["post-16145","post","type-post","status-publish","format-standard","hentry","category-articles","tag-case-history","authors-mallene-et-al"],"acf":[],"_links":{"self":[{"href":"https:\/\/eestiarst.ee\/en\/wp-json\/wp\/v2\/posts\/16145","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/eestiarst.ee\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/eestiarst.ee\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/eestiarst.ee\/en\/wp-json\/wp\/v2\/users\/5"}],"replies":[{"embeddable":true,"href":"https:\/\/eestiarst.ee\/en\/wp-json\/wp\/v2\/comments?post=16145"}],"version-history":[{"count":1,"href":"https:\/\/eestiarst.ee\/en\/wp-json\/wp\/v2\/posts\/16145\/revisions"}],"predecessor-version":[{"id":16146,"href":"https:\/\/eestiarst.ee\/en\/wp-json\/wp\/v2\/posts\/16145\/revisions\/16146"}],"wp:attachment":[{"href":"https:\/\/eestiarst.ee\/en\/wp-json\/wp\/v2\/media?parent=16145"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/eestiarst.ee\/en\/wp-json\/wp\/v2\/categories?post=16145"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/eestiarst.ee\/en\/wp-json\/wp\/v2\/tags?post=16145"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}