{"id":5576,"date":"2015-06-25T12:29:06","date_gmt":"2015-06-25T10:29:06","guid":{"rendered":"http:\/\/eestiarst.dbweb.ee\/?p=5576"},"modified":"2015-06-25T12:29:06","modified_gmt":"2015-06-25T10:29:06","slug":"nmda-receptors-in-neurological-diseases","status":"publish","type":"post","link":"https:\/\/eestiarst.ee\/en\/nmda-receptors-in-neurological-diseases\/","title":{"rendered":"NMDA receptors in neurological diseases"},"content":{"rendered":"<p>Calcium flux through NMDA (N-methyl-D-aspartic acid) receptors is thought to play an important role in synaptic plasticity, a physiologic cellular mechanism. Under constant functional activation of NMDA receptors Ca2+ ions induce a number of biochemical intracellular processes, which\u00a0 result in neuronal degeneration. Blocking of this process is a potential treatment target in some neurodegenerative disorders. This short review focuses on a few neurologic conditions in which NMDA antagonism is either already in clinical use or is being actively investigated.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Calcium flux through NMDA (N-methyl-D-aspartic acid) receptors is thought to play an important role in synaptic plasticity, a physiologic cellular mechanism. Under constant functional activation of NMDA receptors Ca2+ ions induce a number of biochemical intracellular processes, which\u00a0 result in neuronal degeneration. Blocking of this process is a potential treatment target in some neurodegenerative disorders. &#8230;<\/p>\n","protected":false},"author":4,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[2],"tags":[1538],"class_list":["post-5576","post","type-post","status-publish","format-standard","hentry","category-articles","tag-review","authors-mark-braschinsky-en"],"acf":[],"_links":{"self":[{"href":"https:\/\/eestiarst.ee\/en\/wp-json\/wp\/v2\/posts\/5576","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/eestiarst.ee\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/eestiarst.ee\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/eestiarst.ee\/en\/wp-json\/wp\/v2\/users\/4"}],"replies":[{"embeddable":true,"href":"https:\/\/eestiarst.ee\/en\/wp-json\/wp\/v2\/comments?post=5576"}],"version-history":[{"count":1,"href":"https:\/\/eestiarst.ee\/en\/wp-json\/wp\/v2\/posts\/5576\/revisions"}],"predecessor-version":[{"id":5577,"href":"https:\/\/eestiarst.ee\/en\/wp-json\/wp\/v2\/posts\/5576\/revisions\/5577"}],"wp:attachment":[{"href":"https:\/\/eestiarst.ee\/en\/wp-json\/wp\/v2\/media?parent=5576"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/eestiarst.ee\/en\/wp-json\/wp\/v2\/categories?post=5576"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/eestiarst.ee\/en\/wp-json\/wp\/v2\/tags?post=5576"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}