The current report provides a survey of 8-year experience of the serum screening of trimester II in Estonia in 1999\u20132006. Maternal serum screening (double\/triple test) of women aged <= 35\/37 years started in autumn 1998 in Tartu, in 2000 in southern Estonia, in 2001 in Tallinn and only in 2003 in the whole of Estonia. In 2006, 91% of pregnant women in Estonia were monitored. The proportion of the pregnancies screened varied from 48% in eastern Estonia to ~ 100% in Tartu and Tallinn (the two biggest cities in Estonia). During the 8 years (1999\u20132006) altogether 60 970 screening tests were performed. Positive serum screening was an indication for amniocentesis (fetal karyotyping) in 2904 (4.76%) cases. Chromosomal abnormalities were detected in 82 (1:36) cases, and Down\u2019s syndrome (DS) in 37 (45%) cases.
\nDetection rate (DR) <\/b>i.e. the proportion of fetuses affected by Down\u2019s syndrome, identified by a screening test or a combination of screening tests. In the study period (1999\u20132006) the DR of serum screening (double\/triple test) in Estonia was 57.8%. In this period 30.3% of DS cases in the age group under under 35\/37 years were diagnosed prenatally. In the advanced maternal age risk group chromosome anomalies have been screened since 1995. During the 12-year period 68% of the DS cases were diagnosed prenatally.
\nIncidence of Down\u2019s Syndrome <\/b>has decreased in Estonia after the introduction of prenatal screening was started: the provisional incidence of DS was 1: 684 and after prenatal screening (1995\u20132006) the incidence of DS is 1: 980 in live birth. During the period 1995\u20132006 when prenatal diagnosis was used in Estonia 46.2% of DS cases were diagnosed prenatally.\u00a0We consider our experience in serum screening successful but a more efficient screening strategy is needed in the future. In 2008 an integrated test providing risk assessment in trimester II (triple test) in combination with nuchal translucency in trimester I will be introduced in Estonia.<\/p>\n","protected":false},"excerpt":{"rendered":"
The current report provides a survey of 8-year experience of the serum screening of trimester II in Estonia in 1999\u20132006. Maternal serum screening (double\/triple test) of women aged <= 35\/37 years started in autumn 1998 in Tartu, in 2000 in southern Estonia, in 2001 in Tallinn and only in 2003 in the whole of Estonia. …<\/p>\n","protected":false},"author":4,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[2],"tags":[1538],"class_list":["post-5810","post","type-post","status-publish","format-standard","hentry","category-articles","tag-review","authors-kai-muru-en","authors-mari-sitska-en","authors-tiia-reimand-en"],"acf":[],"_links":{"self":[{"href":"https:\/\/eestiarst.ee\/en\/wp-json\/wp\/v2\/posts\/5810","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/eestiarst.ee\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/eestiarst.ee\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/eestiarst.ee\/en\/wp-json\/wp\/v2\/users\/4"}],"replies":[{"embeddable":true,"href":"https:\/\/eestiarst.ee\/en\/wp-json\/wp\/v2\/comments?post=5810"}],"version-history":[{"count":1,"href":"https:\/\/eestiarst.ee\/en\/wp-json\/wp\/v2\/posts\/5810\/revisions"}],"predecessor-version":[{"id":5811,"href":"https:\/\/eestiarst.ee\/en\/wp-json\/wp\/v2\/posts\/5810\/revisions\/5811"}],"wp:attachment":[{"href":"https:\/\/eestiarst.ee\/en\/wp-json\/wp\/v2\/media?parent=5810"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/eestiarst.ee\/en\/wp-json\/wp\/v2\/categories?post=5810"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/eestiarst.ee\/en\/wp-json\/wp\/v2\/tags?post=5810"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}