{"id":5850,"date":"2015-06-26T10:25:15","date_gmt":"2015-06-26T08:25:15","guid":{"rendered":"http:\/\/eestiarst.dbweb.ee\/?p=5850"},"modified":"2015-06-26T10:25:15","modified_gmt":"2015-06-26T08:25:15","slug":"bone-metastases-in-prostate-cancer-pathophysiology-and-management","status":"publish","type":"post","link":"https:\/\/eestiarst.ee\/en\/bone-metastases-in-prostate-cancer-pathophysiology-and-management\/","title":{"rendered":"Bone metastases in prostate cancer: pathophysiology and management"},"content":{"rendered":"<p>Prostate cancer metastases into bones are a very serious complication of the disease which reduces quality of life and increases desease-specific mortality. The pathophysiology of bone metastases is a highly intricate process. A member of different types of cytokines and growth factors take part in this process. An understanding of the pathophysiology provides an opportunity\u00a0 for palliation: external beam radiation, radioisotopes, biphosphonates and chemotherapy. Biphosphonates reduce the risk of bone complications. Animal models and molecular investigations allow to develop targets for new pharmaceutical agents. The paper presents a short review of the pathophysiology of bone metastases and therapeutic agents.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Prostate cancer metastases into bones are a very serious complication of the disease which reduces quality of life and increases desease-specific mortality. The pathophysiology of bone metastases is a highly intricate process. A member of different types of cytokines and growth factors take part in this process. An understanding of the pathophysiology provides an opportunity\u00a0 &#8230;<\/p>\n","protected":false},"author":4,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[2],"tags":[1538],"class_list":["post-5850","post","type-post","status-publish","format-standard","hentry","category-articles","tag-review","authors-gennadi-timberg-en","authors-mihhail-zarkovski-en"],"acf":[],"_links":{"self":[{"href":"https:\/\/eestiarst.ee\/en\/wp-json\/wp\/v2\/posts\/5850","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/eestiarst.ee\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/eestiarst.ee\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/eestiarst.ee\/en\/wp-json\/wp\/v2\/users\/4"}],"replies":[{"embeddable":true,"href":"https:\/\/eestiarst.ee\/en\/wp-json\/wp\/v2\/comments?post=5850"}],"version-history":[{"count":1,"href":"https:\/\/eestiarst.ee\/en\/wp-json\/wp\/v2\/posts\/5850\/revisions"}],"predecessor-version":[{"id":5851,"href":"https:\/\/eestiarst.ee\/en\/wp-json\/wp\/v2\/posts\/5850\/revisions\/5851"}],"wp:attachment":[{"href":"https:\/\/eestiarst.ee\/en\/wp-json\/wp\/v2\/media?parent=5850"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/eestiarst.ee\/en\/wp-json\/wp\/v2\/categories?post=5850"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/eestiarst.ee\/en\/wp-json\/wp\/v2\/tags?post=5850"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}