CRP is, among other roles, considered a biomarker of knee osteoarthritis (KOA). The aim of the study was to investigate the structures or changes of the knees wich are related to the increased concentration of serum hs-CRP. A symptomatic cohort aged 34\u201354 years (101 women and 60 men) and residing in one community was studied. The OA of the tibio-femoral (TF) and patello-femoral (PF) joints was assessed radiographically. In 115 cases the knee pouches and ligaments were examined sonographi-cally. S-hs-CRP was measured by a particle-enchanced immunoturbidimetric assay (Hitachi 912). In data analysis non-parametric statistics were used. The S-hs-CRP value varied from 0 to 25 mg\/L, the median being 1.6 for men and 1.0 mg\/L for women (p = 0.003). The hs-CRP values were strongly dependent on the BMI of the sub-jects, \u03c1 = 0.314, p = 0.016 (M); \u03c1 = 0.616, p = 0.0000 (W). The hs-CRP values were higher in women with tibial and \/or femoral osteophytes (p = 0.003). On ultrasound investigation part of the women showed narrowing of the PF cartilage, which correlated also with the increased level of hs-CRP (\u03c1 = 0.323, p=0.005). The variability of hs-CRP in the regression model, accounting for the above factors, reached 43% in women and 34% in men. In the studied cohort increased serum hs-CRP concentration is related to several factors: gender, BMI, narrowing of the cartilage in the PF joint in women and presence of finger pain and osteophytes in the knee joint in men.<\/p>\n","protected":false},"excerpt":{"rendered":"
CRP is, among other roles, considered a biomarker of knee osteoarthritis (KOA). The aim of the study was to investigate the structures or changes of the knees wich are related to the increased concentration of serum hs-CRP. A symptomatic cohort aged 34\u201354 years (101 women and 60 men) and residing in one community was studied. …<\/p>\n","protected":false},"author":4,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[2],"tags":[1540],"class_list":["post-6286","post","type-post","status-publish","format-standard","hentry","category-articles","tag-research","authors-agu-tamm-en","authors-ann-tamm-en","authors-karin-veske-en","authors-maret-vija-en","authors-ulle-hansen-en"],"acf":[],"_links":{"self":[{"href":"https:\/\/eestiarst.ee\/en\/wp-json\/wp\/v2\/posts\/6286","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/eestiarst.ee\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/eestiarst.ee\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/eestiarst.ee\/en\/wp-json\/wp\/v2\/users\/4"}],"replies":[{"embeddable":true,"href":"https:\/\/eestiarst.ee\/en\/wp-json\/wp\/v2\/comments?post=6286"}],"version-history":[{"count":1,"href":"https:\/\/eestiarst.ee\/en\/wp-json\/wp\/v2\/posts\/6286\/revisions"}],"predecessor-version":[{"id":6287,"href":"https:\/\/eestiarst.ee\/en\/wp-json\/wp\/v2\/posts\/6286\/revisions\/6287"}],"wp:attachment":[{"href":"https:\/\/eestiarst.ee\/en\/wp-json\/wp\/v2\/media?parent=6286"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/eestiarst.ee\/en\/wp-json\/wp\/v2\/categories?post=6286"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/eestiarst.ee\/en\/wp-json\/wp\/v2\/tags?post=6286"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}