{"id":7658,"date":"2016-04-26T14:21:05","date_gmt":"2016-04-26T12:21:05","guid":{"rendered":"http:\/\/eestiarst.ee\/en\/?p=7658"},"modified":"2016-04-26T14:21:05","modified_gmt":"2016-04-26T12:21:05","slug":"the-influence-of-host-genetic-factors-on-the-susceptibility-of-hiv-and-hcv-infections","status":"publish","type":"post","link":"https:\/\/eestiarst.ee\/en\/the-influence-of-host-genetic-factors-on-the-susceptibility-of-hiv-and-hcv-infections\/","title":{"rendered":"The influence of host genetic factors on the susceptibility of HIV and HCV infections"},"content":{"rendered":"<p><strong>Background and aim.<\/strong> Susceptibility to HIV and HCV is influenced by a variety of factors including host genetics. Many polymorphisms of HIV pathogenesis related genees (e.g. <em>CCR5, CCL3L1<\/em>) have been associated with susceptibility to HIV infection among sexually infected subjects. It is unknown whether the genetic variability of <em>CCL3L1<\/em> and <em>CCR5<\/em> influences the acquisition of multiple blood-borne infections (e.g. HCV and HIV ) occurring commonly among persons who inject drugs (PWID). We investigated whether <em>CCR5<\/em> haplotypes and <em>CCL3L1<\/em> gene copy number influence HIV-1 and HCV seropositivity among Caucasian PWID.<\/p>\n<p><strong>Methods.<\/strong> In total, 374 Caucasian PWID and 500 blood donors from Estonia (seronegative for HIV, HCV and HBV) were included in the study.The <em>CCL3L1 <\/em>copy number and nine <em>CCR2-CCR5<\/em> polymorphisms were determined by real-time PCR. The. <em>CCR5<\/em> haplotypes (HHA to HHG*2) were defined using an evolutionary based classification. In addition, uni- and multivariate logistic regression analysis was used to evaluate the associations of <em>CCR5<\/em> haplotypes and <em>CCL3L1<\/em> gene copy number with HIV and\/ or HCV seropositivity.<\/p>\n<p><strong>Results and conclusions.<\/strong> Overall distribution of <em>CCR5 <\/em>haplotypes and <em>CCL3L1<\/em> copy number was similar to that of other Caucasian populations. The PWID possessing <em>CCR5 <\/em>HHG*1 had decreased odds to be HCV seropositive (OR 0.37; 95% CI 0.16\u20130.82) compare with the PWID possessing other haplotypes. This association remained significant after adjustment for co-factors. The PWID with higher <em>CCL3L1<\/em> copy number than population median (2) had decreased odds of HIV acquisition (OR 0.49; 95% CI 0.29\u20130.81); the association remained significant in a multivariate model. Among PWID with extensive exposure to HCV and HIV, <em>CCL3L1<\/em> copy number is a risk factor for HIV seropositivity. The <em>CCR5 <\/em>HHG*1 influences HCV seropositivity so that the possession of this haplotype dimishes susceptibility to HCV. These results highlight the importance of the <em>CCR5-CCL3L1<\/em> axis in susceptibility to HIV and HCV infections.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Background and aim. Susceptibility to HIV and HCV is influenced by a variety of factors including host genetics. Many polymorphisms of HIV pathogenesis related genees (e.g. CCR5, CCL3L1) have been associated with susceptibility to HIV infection among sexually infected subjects. It is unknown whether the genetic variability of CCL3L1 and CCR5 influences the acquisition of &#8230;<\/p>\n","protected":false},"author":5,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[2],"tags":[1540],"class_list":["post-7658","post","type-post","status-publish","format-standard","hentry","category-articles","tag-research","authors-kristi-huik-en"],"acf":[],"_links":{"self":[{"href":"https:\/\/eestiarst.ee\/en\/wp-json\/wp\/v2\/posts\/7658","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/eestiarst.ee\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/eestiarst.ee\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/eestiarst.ee\/en\/wp-json\/wp\/v2\/users\/5"}],"replies":[{"embeddable":true,"href":"https:\/\/eestiarst.ee\/en\/wp-json\/wp\/v2\/comments?post=7658"}],"version-history":[{"count":1,"href":"https:\/\/eestiarst.ee\/en\/wp-json\/wp\/v2\/posts\/7658\/revisions"}],"predecessor-version":[{"id":7659,"href":"https:\/\/eestiarst.ee\/en\/wp-json\/wp\/v2\/posts\/7658\/revisions\/7659"}],"wp:attachment":[{"href":"https:\/\/eestiarst.ee\/en\/wp-json\/wp\/v2\/media?parent=7658"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/eestiarst.ee\/en\/wp-json\/wp\/v2\/categories?post=7658"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/eestiarst.ee\/en\/wp-json\/wp\/v2\/tags?post=7658"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}