{"id":7711,"date":"2016-05-25T09:44:56","date_gmt":"2016-05-25T07:44:56","guid":{"rendered":"http:\/\/eestiarst.ee\/en\/?p=7711"},"modified":"2016-05-25T09:44:56","modified_gmt":"2016-05-25T07:44:56","slug":"macrophage-activation-syndrome-as-a-complication-of-systemic-juvenile-idiopathic-arthritis-in-a-7-year-old-girl","status":"publish","type":"post","link":"https:\/\/eestiarst.ee\/en\/macrophage-activation-syndrome-as-a-complication-of-systemic-juvenile-idiopathic-arthritis-in-a-7-year-old-girl\/","title":{"rendered":"Macrophage activation syndrome as a complication of systemic juvenile idiopathic arthritis in a 7-year-old girl"},"content":{"rendered":"<p><span style=\"color: #000000; font-family: Calibri;\">Systemic arthritis is a subtype of juvenile idiopathic arthritis (JIA) with a frequency of 4-17% in the whole group. Macrophage activation syndrome (MAS) is a serious, potentially life-threatening complication of sJIA, characterized by excessive activation and proliferation of T-lymphocytes and macrophages, resulting in overproduction of proinflammatory cytokines and development of typical clinical-laboratory changes.<\/span><\/p>\n<p><span style=\"color: #000000; font-family: Calibri;\">The case describes development of MAS in a 7-year-old girl five years after being diagnosed with JIA. A year after the diagnosis the disease became continuously relapsing and non-responsive to treatment neither with synthetic nor with first- and second-line biological disease modifying antirheumatic drugs.<\/span><\/p>\n<p><span style=\"color: #000000; font-family: Calibri;\">The development of MAS could have been provoked either by the active main disease, the medications used or pneumocyst-caused pneumonia. For the treatment of MAS, high-dose intravenous glucocorticoids and cyclosporine-A were used, which led to the improvement of the process.<\/span><\/p>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Systemic arthritis is a subtype of juvenile idiopathic arthritis (JIA) with a frequency of 4-17% in the whole group. Macrophage activation syndrome (MAS) is a serious, potentially life-threatening complication of sJIA, characterized by excessive activation and proliferation of T-lymphocytes and macrophages, resulting in overproduction of proinflammatory cytokines and development of typical clinical-laboratory changes. The case &#8230;<\/p>\n","protected":false},"author":5,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[2],"tags":[1539],"class_list":["post-7711","post","type-post","status-publish","format-standard","hentry","category-articles","tag-case-history","authors-chris-pruunsild-en","authors-jaanika-ilisson-en"],"acf":[],"_links":{"self":[{"href":"https:\/\/eestiarst.ee\/en\/wp-json\/wp\/v2\/posts\/7711","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/eestiarst.ee\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/eestiarst.ee\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/eestiarst.ee\/en\/wp-json\/wp\/v2\/users\/5"}],"replies":[{"embeddable":true,"href":"https:\/\/eestiarst.ee\/en\/wp-json\/wp\/v2\/comments?post=7711"}],"version-history":[{"count":1,"href":"https:\/\/eestiarst.ee\/en\/wp-json\/wp\/v2\/posts\/7711\/revisions"}],"predecessor-version":[{"id":7712,"href":"https:\/\/eestiarst.ee\/en\/wp-json\/wp\/v2\/posts\/7711\/revisions\/7712"}],"wp:attachment":[{"href":"https:\/\/eestiarst.ee\/en\/wp-json\/wp\/v2\/media?parent=7711"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/eestiarst.ee\/en\/wp-json\/wp\/v2\/categories?post=7711"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/eestiarst.ee\/en\/wp-json\/wp\/v2\/tags?post=7711"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}