REVIEW – June 2017

Humanin – a small peptide with big tasks?

Authors: Henery Kroon, Mall Eltermaa, Anu Reigo, Inga Karu, Arno Ruusalepp, Joel Starkopf, Sulev Kõks

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In 2001, humanin – a small peptide – was first described and named a potential mitochondrial signalling molecule. Since its discovery a wide range of positive characteristics of this molecule have been described: antiapoptotic, cytoprotection through various mechanisms. This peptide is linked to age-related diseases like diabetes and atherosclerosis. The purpose of this article was to share information about humanin since it is a peptide serving as a target for potential medication design.