REVIEW – September 2022

Hypertrophic cardiomyopathy

Authors: Polina Piskoppel

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Hypertrophic cardiomyopathy is one of the most common genetic heart conditions, which has multiple etiologies and modest symptoms. Early diagnosis, sudden death risk assessment and therapy are the most important aspects of HCM. Genetic testing and counselling of relatives is also crucial. Diagnosis of HCM is mostly based on history, physical examination and imaging studies (mainly echocardiography). Therapy is directed towards relief of symptoms and prevention of sudden cardiac death. Most people with HCM have normal lifespan, but quality of life can be greatly affected when symptoms appear. Hence it is important to explore gene therapy and find medications which affect the pathogenesis of the condition.