Pemphigus foliaceus (PF) is a rare autoimmune bullous skin disease which is characterized by formation of intraepidermal blisters due to presence of autoantibodies against desmoglein 1. Clinically, flaccid blisters and crusted, scaly erosions are seen preferably in seborrheic skin areas like the scalp, face and upper trunk. Mild disease can be treated with topical superpotent corticosteroids, in severe and widespread PF the first-line treatment is systemic corticosteroids and adding of adjuvants might be needed. In this article we present a case of a 14-year-old adolescent who was hospitalized with widespread rash. He was diagnosed with pemphigus foliaceus and has been treated with corticosteroids, azathioprine, mycophenolate mofetil and intravenous immunoglobulin to date.