PSA is still the most widely used and specific oncological marker for diagnosing different prostate conditions and for follow-up after or during treatment. Besides other methods as DRE and TRUS, PSA is the most exact and informative diagnostic instrument for prostate cancer. However, very often it is not enough to use only PSA values because of their limitations. Research on PSA kinetics has developed considerably in recent years. The use of different PSA surrogates like PSAV, PSAD and PSADT may improve the diagnostic possibilities and treatment options of prostate cancer.