Abstract

Telmisartan is a highly efficient antihypertensive drug wich belongs to the group of angiotensine type II blockers with high selectivity to AT1 receptors. Having a slow onset of action and a long-term antihypertensive effect, telmisartan can be prescribed for use once a day. The preparation causes no noticeable fluctuations in blood pressure. Telmisartan reduces endothelial function, has antioxydative, antiatherogenic and antitrombotic, as well as nephroprotective effects. The preparation is well tolerated and rarely causes side effects.

Forty-six patients with arterial hypertension underwent office and 24-hour ambulatory blood pressure measurements before treatment and after four-week treatment with telmisartan; average dosage was 59 ± 20.2 mg. Good, very good and satisfactory antihypertensive effects were observed in 80% of the patients. According to the data of office blood pressure measurements, mean systolic blood pressure and diastolic blood pressure decreased significantly: 13.2 mm Hg and 8.0 mm Hg, respectively. According to the data of ambulatory blood pressure measurements, systolic blood pressure and diastolic blood pressure decreased on average by 10.5 mm Hg and 6,4 mm Hg, respectively. Telmisartan tolerance was considered very good: only one patient had a side effect (headache).