Candesartan is a highly efficient antihypertensive drug which belongs to the group of the angiotensine II type blockers with a high selectivity to AT1 receptors. Unfortunately, this class of antihypertensive drugs is still the least used in clinical practice in Estonia.
Aim: To assess the efficacy and tolerability of telmisartan in patients with essential hypertension living in Estonia.
Material and methods: Thirty-six patients with arterial hypertension underwent office and 24-hour ambulatory blood pressure measurements before treatment and after four weeks of treatment with candesartan; average dosage was 14.4±4.2 mg.
Results: A good, very good and satisfactory antihypertensive effect was observed in 80.6% of the patients. According to the data of office blood pressure measurements, mean systolic and diastolic blood pressure decreased significantly, by 12.7 mmHg and 8.0 mmHg, respectively; p<0.05. According to the data of ambulatory blood pressure measurements, systolic and diastolic blood pressure decreased on average by 11.8 mmHg and 7.7 mmHg, respectively; p<0.05. Four patients had nonsignificant side effects.
Conclusion: Candesartan is a highly efficient antihypertensive drug for treatment of patients with mild to moderate arterial hypertension. Candesartan tolerance was considered very good.