Breast cancer is the most common malignancy among females worldwide. Despite an increase in incidence, a decrease in mortality from breast cancer is achieved in developed countries owing to better screening and therapy. Breast cancer therapy is a complex of surgical therapy, medical therapy and radiotherapy. The current article gives an overview of current advances and possible developments in breast cancer therapy. Surgical therapy has moved in the direction of less agressive procedures using conservative surgery and sentinel node biopsy. Medical therapy comprises hormonal, biological and chemotherapy in adjuvant and metastatic settings. Treatment decisions are tailored using different prognostic and predictive characteristics.