REVIEW – February 2009

Etiology of Hodgkin’s lymphoma


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Although Hodgkin’s lymphoma (HL) has been thoroughly studied there is yet no good answer to the question of how to avoid Hodgkin’s lymphoma. The role of Epstein-Barr virus (EBV) in the transformation of B-lymphocytes has been most convincingly proved. Evidently, EBV-positive HL and EBV-negative HL have different etiologies. The other etiological or risk factors of HL have been studied and pointed out: measles’ virus, Semian virus 40, human immunodeficiency virus (HIV), heredity, chemical substances (trichloroethylene), ionizing radiation, peculiarity of the living or working environment. However, these possible etiological and/or risk factors for formation of HL have not been proved as reliably as the role of EBV. Investigation of the above mentioned etiological factors allows to conclude that more attention should be paid to the theoretical basis of the dependence of the dynamics of regulation of lymphocytes and EBV on the extracorporeal and intracorporeal electric (magnetic, electromagnetic, radiation, bioelectromagnetic) processes. Practical studies of the pathogenesis of Hodgkin’s lymphoma would be of utmost importance.