Chronic pain usually presents as an independently established syndrome, frequently with accompanying symptoms such as depression, anxiety, sleep problems and fatigue. Multiple mechanisms are involved in sustaining the condition and making it challenging from the point of view of treatment. Different types of pain within the spectrum of chronic pain are addressed, which help to manage its components. The article focuses on considerations of practical management, including combination pharmacotherapy as an emerging practice. Recommendations are made on various chronic pain conditions on the basis of currently available level A and B evidence. Additionally, non-pharmacological options and the multi-disciplinary approach are emphasized in dealing with this condition.